Identifying Impurities in Liquids of Pharmaceutical Vials

Abstract: The presence of visible particles in pharmaceutical products is a critical quality issue that demands strict monitoring. Recently, Convolutional Neural Networks (CNNs) have been widely used in industrial settings to detect defects, but there remains a gap in the literature concerning the detection of particles floating in liquid substances, mainly due to the lack of publicly available datasets. In this study, we focus on the detection of foreign particles in pharmaceutical liquid vials, leveraging two state-of-the-art deep-learning approaches adapted to our specific multiclass problem. The first methodology employs a standard ResNet-18 architecture, while the second exploits a Multi-Instance Learning (MIL) technique to efficiently deal with multiple images (sequences) of the same sample. To address the issue of no data availability, we devised and partially released an annotated dataset consisting of sequences containing 19 images for each sample, captured from rotating vials, both with and without impurities. The dataset comprises 2,426 sequences for a total of 46,094 images labeled at the sequence level and including five distinct classes. The proposed methodologies, trained on this new extensive dataset, represent advancements in the field, offering promising strategies to improve the safety and quality control of pharmaceutical products and setting a benchmark for future comparisons.

Citation:

Rosati, Gabriele; Marchesini, Kevin; Lumetti, Luca; Sartori, Federica; Balboni, Beatrice; Begarani, Filippo; Vescovi, Luca; Bolelli, Federico; Grana, Costantino "Identifying Impurities in Liquids of Pharmaceutical Vials" 2024 27th International Conference on Pattern Recognition (ICPR), Kolkata, India, Dec 01-05, 2024

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